A Novel Pyrazolo[1,5-a]pyrimidine Is a Potent Inhibitor of Cyclin-Dependent Protein Kinases 1, 2, and 9, Which Demonstrates Antitumor Effects in Human Tumor Xenografts Following Oral Administration

Symplectic ID:

2027399

Source:

dimensions

This is the preferred source?:

1

Last Synced with Symplectic:

Friday, 28 August, 2026 - 22:27

DOI:

10.1021/jm100732t

Publication Date:

Thursday, 23 December, 2010

First Page:

8508

Last Page:

8522

Keywords:

32 Biomedical and Clinical Sciences

3211 Oncology and Carcinogenesis

Biotechnology

Rare Diseases

Cancer

5.1 Pharmaceuticals

Cancer

Administration, Oral

Animals

Antineoplastic Agents

Biological Availability

Blood Proteins

Cell Cycle

Cell Line, Tumor

Cell Proliferation

Crystallography, X-Ray

Cyclin-Dependent Kinase 2

Cyclin-Dependent Kinase 9

Female

Humans

In Vitro Techniques

Mice

Mice, Nude

Microsomes, Liver

Models, Molecular

Phosphorylation

Protein Binding

Pyrazoles

Pyrimidines

Stereoisomerism

Structure-Activity Relationship

Xenograft Model Antitumor Assays

Authors:

Heathcote, DA

Patel, H

Kroll, SHB

Hazel, P

Periyasamy, M

Alikian, M

Kanneganti, SK

Jogalekar, AS

Scheiper, B

Barbazanges, M

Blum, A

Brackow, J

Authors list has been truncated:

1

Editors list has been truncated:

Publisher:

American Chemical Society (ACS)

ISSN:

0022-2623

Journal Title:

Journal of Medicinal Chemistry

Volume:

53

Issue:

24

ID at Source:

pub.1055951770

Open access:

Publication Date - Display month part?:

Publication Date - Display day part?:

SSO preference:

chem1933