Thienopyrimidinone Based Sirtuin‑2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket

Sundriyal S, Moniot S, Mahmud Z, Yao S, Di Fruscia P, Reynolds CR, Dexter DT, Sternberg MJE, Lam EW-F, Steegborn C, Fuchter MJ

9 March 2017

Journal article

Journal:

Journal of Medicinal Chemistry

Volume:

Issue:

American Chemical Society (ACS)

pp.

1928 - 1945

No abstract available

Keywords:

3404 Medicinal and Biomolecular Chemistry

34 Chemical Sciences

5.1 Pharmaceuticals

Binding Sites

Crystallography, X-Ray

Ligands

Molecular Docking Simulation

Sirtuin 2

Structure-Activity Relationship

Thienopyridines

DOI